Modelos discretos em ecologia matematica

Orientador: Alejandro B. EngelDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Ciencia da ComputaçãoResumo: Não informado.Abstract: Not informed.MestradoMestre em Matemática Aplicad

Equilibrium analysis of a yellow Fever dynamical model with vaccination.

We propose an equilibrium analysis of a dynamical model of yellow fever transmission in the presence of a vaccine. The model considers both human and vector populations. We found thresholds parameters that affect the development of the disease and the infectious status of the human population in the presence of a vaccine whose protection may wane over time. In particular, we derived a threshold vaccination rate, above which the disease would be eradicated from the human population. We show that if the mortality rate of the mosquitoes is greater than a given threshold, then the disease is naturally (without intervention) eradicated from the population. In contrast, if the mortality rate of the mosquitoes is less than that threshold, then the disease is eradicated from the populations only when the growing rate of humans is less than another threshold; otherwise, the disease is eradicated only if the reproduction number of the infection after vaccination is less than 1. When this reproduction number is greater than 1, the disease will be eradicated from the human population if the vaccination rate is greater than a given threshold; otherwise, the disease will establish itself among humans, reaching a stable endemic equilibrium. The analysis presented in this paper can be useful, both to the better understanding of the disease dynamics and also for the planning of vaccination strategies

Uma abordagem deterministica da interação de doenças AIDS e TB num presidio

Orientador: Rodney Carlos BassaneziTese (doutorado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação CientíficaResumo: Não informado.Abstract: Not informed.DoutoradoDoutor em Matemática Aplicad

Modelling congenital transmission of Chagas` disease

The successful elimination of vectorial and transfusional transmission of Chagas` disease from some countries is a result of the reduction of domestic density of the primary vector Triatoma infestans, of almost 100% of coverage in blood serological selection and to the fact that the basic reproductive number of Chagas` disease is very close to one (1.25). Therefore, congenital transmission is currently the only way of acquiring Chagas` Disease in such regions. In this paper we propose a model of congenital transmission of Chagas` disease. Its aim is to provide an estimation of the time period it will take to eliminate this form of transmission in regions where vetorial transmission was reduced to close to zero, like in Brazil. (C) 2009 Elsevier Ireland Ltd. All rights reserved.FAPES

Modeling vaccine preventable vector-Borne infectations: yellow fever as a case study

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOIn this paper, we propose and simulate a deterministic model for a vector-borne disease in the presence of a vaccine. The model allows the assessment of the impact of an imperfect vaccine with various characteristics, which include waning protective immunity, incomplete vaccine-induced protection and adverse events. We find three threshold parameters which govern the existence and stability of the equilibrium points. Our stability analysis suggests that the reduction in the mosquito fertility theoretically is the most effective factor of reducing disease prevalence in both low and high transmission areas. To illustrate the theoretical results, the model is simulated by the example of yellow fever. We also perform sensitivity analyses to determine the importance of both vaccine-induced mortality rate and disease-induced mortality rate for determining a control strategy. We found that there is an optimum vaccination rate, above which people die by the vaccination and below which people die by the disease.In this paper, we propose and simulate a deterministic model for a vector-borne disease in the presence of a vaccine. The model allows the assessment of the impact of an imperfect vaccine with various characteristics, which include waning protective immunity, incomplete vaccine-induced protection and adverse events. We find three threshold parameters which govern the existence and stability of the equilibrium points. Our stability analysis suggests that the reduction in the mosquito fertility theoretically is the most effective factor of reducing disease prevalence in both low and high transmission areas. To illustrate the theoretical results, the model is simulated by the example of yellow fever. We also perform sensitivity analyses to determine the importance of both vaccine-induced mortality rate and disease-induced mortality rate for determining a control strategy. We found that there is an optimum vaccination rate, above which people die by the vaccination and below which people die by the disease242/3193216FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOsem informaçãosem informaçã

Contagious Criminal Career Models Showing Backward Bifurcations: Implications for Crime Control Policies

We provide a theoretical framework to study how criminal behaviors can be treated as an infectious phenomenon. There are two infectious diseases like models that mimic the role of convicted criminals in contaminating individuals not yet engaged in the criminal career. Equilibrium analyses of each model are studied in detail. The models proposed in this work include the social, economic, personal, and pressure from peers aspects that can, theoretically, determine the probability with which a susceptible individual with criminal propensity engages in a criminal career. These crime-inducing parameters are treated mathematically and their inclusion in the model aims to help policy-makers design crime control strategies. We propose, to the best of our knowledge by the first time in quantitative criminology, the existence of thresholds for the stability of crime-endemic equilibrium which are the equivalent to the “basic reproduction number” widely used in the mathematical epidemiology literature. Both models presented the phenomena of backward bifurcation and breaking-point when the contact rates are chosen as bifurcation parameters. The finding of backward bifurcation in both models implies that there is an endemic equilibrium of criminality even when the threshold parameter for contagion is below unit, which, in turn, implies that control strategies are more difficult to achieve considerable impact on crime control

Modeling the emergence of HIV-1 drug resistance resulting from antiretroviral therapy: insights from theoretical and numerical studies.

The use of antiretroviral therapy has proven to be remarkably effective in controlling the progression of human immunodeficiency virus (HIV) infection and prolonging patient's survival. Therapy however may fail and therefore these benefits can be compromised by the emergence of HIV strains that are resistant to the therapy. In view of these facts, the question of finding the reason for which drug-resistant strains emerge during therapy has become a worldwide problem of great interest. This paper presents a deterministic HIV-1 model to examine the mechanisms underlying the emergence of drug-resistance during therapy. The aim of this study is to determine whether, and how fast, antiretroviral therapy may determine the emergence of drug resistance by calculating the basic reproductive numbers. The existence, feasibility and local stability of the equilibriums are also analyzed. By performing numerical simulations we show that Hopf bifurcation may occur. The model suggests that the individuals with drug-resistant infection may play an important role in the epidemic of HIV